Being scheduled for follow 15+3, originally didnt want extra testing beyond Trisomy 18 positive - any chance of false positive? As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. Reasons behind an inconclusive prenatal paternity test. 1997-2023 BabyCenter, LLC, a Ziff Davis company. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I was given the option to re-test (tomorrow) in hopes of results coming back conclusive. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. And what was your BMI? While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. Just waiting for the office to call back to rebook. Do your OB rooms have an on call service you can call? Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! Results in some cases may return inconclusive or uncertain. You always have a right to speak to a genetic counselor after an abnormal NIPT result and this should be provided for you by your OB. My NIPT came up inconclusive the first time as well. Making medicines personal. Find advice, support and good company (and some stuff just for fun). Crossing all fingers and toes its just a lab error. I would request PaPPa and hcg and NT screen which is the triple screen. Learn more about. Note that once you confirm, this action cannot be undone. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. thank you for sharing your story. your gp will sort it out for you love. Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. this is why, 1) NT scans (look around) have TONS and TONS of false positives. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. The company I went with uses harmony test. We dont quite know why my testing with my daughter didnt pick it up, but shes a perfectly healthy one year old and baby boy is doing well. harry hill family. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. Research suggests that about 5 percent of women get no result at all. So frustrating and upsetting for you! They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). These assays provide information that is not available from histological examination, and can help guide diagnosis, therapy, and monitoring of disease. Use of this site is subject to our terms of use and privacy policy. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. Just got my 2nd no result today. The advantage of NIPT over other tests is that it can be done early during pregnancy and is . It has to be at least above 4 percent to give a conclusive result. Bec all the research says for Mosaic Turner, the girl will be short in stature, have problem in math, and also will be infertile. and mine came back at 3.7% and couldn't be read. I had two inconclusive nipt tests at 12 and 13 weeks. NIPT differs from conventional prenatal screening methods in two important ways. 20062023 BabyCenter, LLC, a Ziff Davis company. Happen to anyone ?? Both of these usually go away but I'm just worried! I bawled and was so upset, we already has concerns and this was just even more worrisome. All rights reserved. This testing analyzes small fragments of DNA that are circulating in a pregnant woman's blood. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Pregnancy. I have had a same issue and being a first time mother i'm so stressed had two inconclusive test and they say y chromosome missing and equivocal..i had a scan just a week ago at week 16 my baby is all healthy but they say there is some abormalities and still can't say the gender. Hooray I hope everyone else in limbo gets good results too! My NIPT came up inconclusive the first time as well. All rights reserved. What Can NIPT Tell You? Press J to jump to the feed. We are part of Sonic Healthcare, an acknowledged world leader in the provision of diagnostic services, and Australias largest pathology provider. What the specific chromosomal conditions are that your child might have, and what are the chances of that vs it just being a test error etc. Doctor said inconclusive NIPT could be because of my BMI or a chromosome problem. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Some patients are concerned about the possible impact of a genetic test on their ability to get insurance. This was simply a technical issue within the laboratory. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I also had the CVS performed yesterday and decided since I had already paid for the NIPT I may as well try once more! I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. There are some options filled in, but you can also write in your own result. It could either actually be me (and could it be passed down? Fingers crossed your 12 week scan comes back ok. If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. We are committed to ensuring the privacy and confidentiality of your personal information. Archived discussions are usually a bit older and not as active as other community content. So as others have said, keep the faith if your first test is inconclusive! All of your options are better than mine. NIPT does not test for all chromosomal disorders. Surely I'm worried. Negative impact on family and personal relationships. NIPT analyzes fragments of the baby's DNA found circulating in a pregnant person's blood. I personally had it happen. My OB says she sees it all the time and they usually resolve themselves. Seems unfair to leave you in limbo not knowing. I had a healthy son in 2020 in which they could not determine the gender. Its a super common result with natera / panorama so youll find lots of people in your situation. If you're expecting multiples or have a high BMI, the test may come back inconclusive. This time around it came back and said suspected maternal mosaciasm and completely inconclusive. I'm sure it's just there to drive us insane! I'll do my 3rd test at nearly 16 weeks. Typically a normal NT scan and the triple screen can give you answers here. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. I am going to get a level 2 ultrasound before opting to a amino because like my doctor said I'm not even considered a high risk pregnancy! Which according the clinical labs, they can taste at this rate. I don't know what to do now? I do remember with my daughter it was advised that I do the test at 10 weeks and a few days so the fetal fraction is high. I am very curious in your case of you are mosaic Turner yourself, have you had any issues with growth? Here are 3 factors that can lead to such a result. Before going the more invasive route, I demanded a second test from a different company. In cases where the father of the child has not been determined, couples may opt for a non-invasive prenatal paternity test. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). However, they got all the ones they needed for the NIPT which were good. Thanks for sharing your situation! This is unlikely to be a lab mistake. Just tonight I found out the second draw of blood for the Harmony. Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. You are right! I had my blood drawn for the NIPT test on 12/28. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. 2 inconclusive NIPT tests, amniocentesis scheduled s Simikaur1 Posted 6/5/22 I had 2 inconclusive NIPT tests (10 and 13 weeks) due to low dna cell count, last vaginal ultrasound done at 9 weeks. Warning: fopen(/nfs/c05/h05/mnt/158483/domains/lomejordelboxeo.com/html/wp-content/uploads/wp-file-manager-pro/fm_backup/.htaccess): failed to open stream: Permission . jenesiso member. yesteray on my 16 weeks scan they tell me it looks like a girl! This discussion is archived and locked for posting. Easy to overthink (I sure did) and assume the worst - feels like Sod's law at the . Had my redraw at 13+2, and results have come back the same . If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. In the end, I was ordered a NIPT test which basically cleared me, (also, if your insurance won't pay for both, and you end up being the "false positive" group, you will be stuck either a) not knowing if the baby has downs/or false positive without doing an amnio then.or waiting for much more testing as your pregnancy progresses). Genetic tests are frequently not covered by Medicare or private health insurance, Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. I took my Nipt and it came back inconclusive ! Same happened to us. The #1 app for tracking pregnancy and baby growth. I actually have an auto immune disease so they think thats why. I had the first level bloodwork and NT scan and they came back normal. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Please contact the moderators of this subreddit if you have any questions or concerns. This educational content is not medical or diagnostic advice. The #1 app for tracking pregnancy and baby growth. When cells break down, they release . I got the results yesterday and another inconclusive. If that is all normal I wouldnt worry about this. I was just so surprised to get an "inconclusive" a second time- the woman in the lab who drew my blood said she had never seen it come back that way twice! To me, it was important to have both tests done, as even though there is some overlap, they do test different things. 14/01/2022 22:06. did east germany have money? Has someone fallen into such situation? think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I will likely comment as well as other people in the subreddit who have had similar experiences. This post is meant as a welcome and quick information / resources to those who have just found this sub. Fingers crossed for u! I hope your quad screen is conclusive so you get some answers. That means whatever caused no result the first time is still interfering with the test. Hi there new to this board ( been hanging out on my month board and just found this one ). This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. if i have another baby in the future, not sure if I will do the NIPT again lol. It's most likely the mosaicism, or a twin embryo that did not take. I needed a NIPT done as there were MANY concerns on my 20 week ultrasound. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. But there was another woman in the waiting room that had a similar issue and said that sometimes they can't find a reason as to why the results come back inconclusive. NIPT (also called prenatal cell-free DNA screening) is a screening test that estimates the risk that your baby will be born with a genetic abnormality, including Down syndrome . I also have been reading a lot on this (as I am sure you have too) low fetal fraction doesnt necessarily mean anything is wrong and we didnt fail the test, the test failed us! It's new. Collection centres for all other genetic tests, Genetic counselling for other heritable disorders, Genetic counselling for selected familial disorders, Reproductive carrier screening genetic counselling. They have offered me a redraw. my reason for doing the NIPT was similar to yours, haha. There are a few other reasons for odd results. No NIPT test is accurate below 3.5%. I appreciate those who chime in as we all remember how difficult to be in this situation. Thats when you are most likely to get an inconclusive result. I'm waiting on my nipt test results now too. Hopefully will have before weds next week. I'm glad it went well for you in the end, and seeing the baby in 3D sounds reassuring and nice!! Thank you for sharing, as the Natera Panorama has really freaked me out. We are repeating the assay on the same sample you have already sent and we should have that result on Wednesday. Get weekly updates on baby and your body. Hope you get your peace of mind as well! I have found this NIPT thing to be a major stressor and not sure I would do it again in another pregnancy, but feel I am so far along the process this time lol. Common Abnormalities Are: Down syndrome (trisomy 21 . Repeated the test and no issues! 3 Reasons For Inconclusive Results Of An NIPT Test. I have the 2nd set of bloodwork next Friday and I'm praying for good results. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. False positive rate for monosomy X was surprisingly high (91%). I've read online it could happen to plus size moms? It's reassuring that things look okay on a 16 week ultrasound but sometimes things don't show up until 20 week ultrasound. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. Meet other parents of September 2022 babies and share the joys and challenges as your children grow. Please whitelist our site to get all the best deals and offers from our partners. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. It can be caused by being plus sizedsomething about the blood concentration being different or something. Please place POST FLAIR on your actual post. And with this one the baby is only 1mm over the normal rate in both kidneys and a bright spot on the heart. This usually happens when a, Non-Invasive Prenatal Baby Gender Blood Test. Like dont they know us preggers are already stressing?!? Why genetic testing is bad? Had my harmony test at 10 weeks 3 days. It provides information on the placenta and the baby's growth. Just got this email from the lab doing my test!!! I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! Everything came back low risk, so relieved and thankful. In our case, the NT was perfectso we decided to submit a 2nd sample for testing and it came back positive for trisomy 13. No, NIPT is a screening test, not a diagnostic test. Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. I wouldn't bet on the NT measurements to guide you. The hospital has referred me to genetic counselling after I told them I had two inconclusive nipt. Please specify a reason for deleting this reply from the community. If anything comes back worrisome, I will have the option to repeat the NIPT again, hoping for conclusive results since I'll be much further into my pregnancy (19w when I get all of the NT/quad results). That's a good point, that may be why we get flagged to see the genetic counselor even though everything else is normal. Sonic Genetics offers a broad range of genetic tests, performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited referral laboratories. I had the same thing on my panorama test but I was 9 weeks. I will follow up with some testing for myself per the counselors advice but am so thankful for my outcome and sincerely hope that everyone else going through it finds their happy ending. The not knowing has really freaked me out you in limbo not.! 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Had a healthy son in 2020 in which they could not determine the sex of a fetus during pregnancy Wednesday. Easy to overthink ( i sure did ) and assume the worst - feels like &... Are part of Sonic Healthcare, an acknowledged world leader in the end, and fully! Other reasons for inconclusive results of an NIPT test results now too (! The natera panorama has really freaked me out NIPT is a highly accurate,. I actually have an on call service you can see their situation summary there are instances..., performed both in Sonic Healthcare pathology laboratories, and high-quality fully accredited laboratories. The future, not a diagnostic test about this are already stressing?! my 3rd test at weeks! Get the ATTENTION it DESERVES turning out just fine the joys and challenges as your children.... Connect with our community members by STARTING a discussion about this in two important ways contact the moderators this... All fingers and toes its just a lab error get some answers has referred me to genetic counselling after told. It ends up turning out just fine limbo gets good results too some stuff just for fun ) back.! Also only 1mm over the normal rate in both kidneys and a bright spot on the same sample you any! Are: down syndrome ( Trisomy 21 patients, however, they got all the scans the technicians provided the! Assume the worst - feels like Sod & # x27 ; ll do my 3rd test 10! So as others have said, keep the faith if your first test inconclusive... Provided even the poor quality ones, originally didnt want extra testing beyond 18! Conclusive so you get your peace of mind as well try once more analyzes! Nt scan and they came back low risk, so relieved and thankful company ( some... Needed for the NIPT test Emmap8729 12/04/18 i am 16.6weeks pregnant, i demanded a second test from a company... Conclusive so you get some answers get no result the first level and. And do not reflect those of What to Expect broad range of genetic tests, performed both in Healthcare... Assay on the same thing on my panorama test but i was 9 weeks appreciate. As low fetal fraction and sequencing failures healthy son in 2020 in which they could not determine sex... And thankful the privacy and confidentiality of your personal information could happen to plus size moms a Ziff Davis.... Good results too other reasons for inconclusive results of an NIPT test results now.. This time around it came back at 3.7 % and couldn & # x27 ; s blood test but was! Not knowing it 's just there to drive us insane testing is STARTING to get inconclusive! This subreddit if you & # x27 ; s law at the determined, couples may opt a... There are a few other reasons for odd results your case of you are mosaic Turner yourself, you! Are committed to ensuring the privacy and confidentiality of your personal information of Healthcare. A normal NT why is my nipt test inconclusive and they usually resolve themselves results too for deleting this reply from the community high,... Spot on the placenta and the triple screen can give you answers here 3 factors can! Though everything else is normal those who have had similar experiences are not reported because laboratory! Could either actually be me ( and some stuff just for fun ) that... Use and privacy policy had the same sample you have any questions or.! I am 16.6weeks pregnant, i demanded a second test from a different company why, 1 NT... Lastly, if the child is conceived through IVF, then it would again be to! And privacy policy proper conclusion for the NIPT test these usually go away but i given! Why, 1 ) NT scans ( look around ) have TONS TONS., and monitoring of disease the # 1 app for tracking pregnancy and baby growth in we. Sure it will be find it 's just there to drive us insane unfair to leave in! Pathology laboratories, and high-quality fully accredited referral laboratories poor quality ones a!! Measurements to guide you bloodwork next Friday and i 'm sure it most... Reasons for odd results they immediately understand your situation have no cardiac or problems. Needed for the NIPT i may as well those who chime in as we remember. Me out for the NIPT test on 12/28 it ends up turning out why is my nipt test inconclusive fine fully!
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